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Concise Reviews: Stem Cells and Kidney Regeneration: An Update
Julia Marcheque1, Benedetta Bussolati2, Marie Csete3,4
1GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, California.
Stem Cells Translational Medicine
|October 11, 2018
Summary
Stem cell therapies show promise for kidney disease, but inconsistent results hinder progress. Standardizing stem cell methods and animal models is crucial for reliable preclinical data and future patient treatments.
Area of Science:
- Nephrology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Stem cell therapies are being developed for acute and chronic kidney injury.
- Preclinical studies show potential for stem cells to restore renal function.
- The existing literature contains contradictory results, impeding translation.
Purpose of the Study:
- To review reasons for discrepancies in stem cell research for kidney diseases.
- To identify challenges in translating renal regenerative therapies.
- To propose solutions for advancing the field of renal regeneration.
Main Methods:
- Analysis of existing literature on stem cell applications in kidney disease models.
- Identification of methodological differences in stem cell derivation and culturing.
- Evaluation of variability in preclinical animal models of kidney injury.
Main Results:
- Discrepancies arise from varied stem cell culture methods and non-standardized animal models.
- Lack of harmonized protocols for stem cell characterization, handling, and delivery contributes to inconsistent outcomes.
- These inconsistencies complicate the interpretation of preclinical data.
Conclusions:
- Standardized, rigorous protocols for stem cell research are essential for reproducible results.
- Development of standardized renal disease models is needed.
- Coordination of methodologies and collaborations will accelerate the translation of stem cell therapies for kidney diseases.
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