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Updated: Feb 4, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis
Jiasheng Xu1, Kexin Li2, Weimin Zhou1
1a Department of vascular surgery , The Second Affiliated Hospital of Nanchang University , Nanchang , People's Republic of China.
Objective:
To investigate the association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and the formation of lower extremities deep venous thrombosis, and to evaluate the etiology of deep venous thrombosis.
Methods:
Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers. Genotype and allelic frequencies were compared between the two groups.
Results:
Genotype frequencies of CC, CT and TT in MTHFR C677 T were 41.58, 25.74 and 32.67% in DVT group, and 58.33, 23.33 and 18.33% in control group, respectively. There was a significant difference in TT genotype frequency between the two groups (P <0.05).
Conclusion:
The frequency of MTHFR 677TT genotype may be correlated with the morbility of DVT.
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