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First Look at Control-IQ: A New-Generation Automated Insulin Delivery System
Sue Brown1,2, Dan Raghinaru3, Emma Emory1
1Center for Diabetes Technology, University of Virginia, Charlottesville, VA.
Diabetes Care
|October 12, 2018
Summary
This pilot study validated the t:slim X2 insulin pump with Control-IQ Technology for type 1 diabetes management. The closed-loop system demonstrated effective glucose control, paving the way for larger clinical trials.
Area of Science:
- Endocrinology
- Biomedical Engineering
- Diabetes Technology
Background:
- Type 1 diabetes management requires continuous glucose monitoring and insulin delivery.
- Closed-loop insulin delivery systems aim to automate glucose control and improve patient outcomes.
- The t:slim X2 insulin pump with Control-IQ Technology represents an advancement in automated insulin delivery.
Purpose of the Study:
- To pilot test the t:slim X2 insulin pump with Control-IQ Technology.
- To validate the closed-loop system's performance for a future large clinical trial.
- To assess the safety and efficacy of automated insulin correction boluses and overnight glucose control.
Main Methods:
- A pilot study involving five patients with type 1 diabetes.
- Utilized the t:slim X2 insulin pump with Control-IQ Technology, integrated with a Dexcom G6 sensor.
- Data collected in an outpatient setting over approximately 37 hours.
Main Results:
- Mean glucose level of 129 mg/dL during closed-loop operation.
- Achieved 87% time in the target glucose range (70-180 mg/dL).
- Minimal time spent below 60 mg/dL (1.1%), with no events overnight.
Conclusions:
- The Control-IQ Technology demonstrated promising results in a pilot trial for type 1 diabetes.
- The system's performance supports its use in larger clinical studies, including the NIH iDCL Trial.
- Automated insulin correction and hypoglycemia safety features show potential for improved diabetes management.
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