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Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight and obesity: findings from

Polina Girchenko1, Marius Lahti-Pulkkinen2, Jari Lahti2

  • 1Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. polina.girchenko@helsinki.fi.

Pediatric Research
|October 12, 2018
PubMed

Insights

Maternal overweight/obesity is linked to offspring regulatory behavior problems, which partially explain neurodevelopmental delays. These issues appear to originate prenatally.

Area of Science:

  • Developmental Psychology
  • Maternal Health
  • Neuroscience

Background:

  • Maternal overweight/obesity and related conditions are associated with adverse neurodevelopmental outcomes in children.
  • The role of offspring regulatory behavior problems as a mediator in this relationship requires further investigation.

Purpose of the Study:

  • To examine the association between maternal overweight/obesity and offspring regulatory behavior problems.
  • To investigate whether offspring regulatory behavior problems mediate the link between maternal overweight/obesity and neurodevelopmental milestones.
  • To explore the association of comorbid maternal disorders with offspring regulatory behavior.

Main Methods:

  • Utilized data from the PREDO Study, including questionnaires on child regulatory behavior (mean age 16.9 days) and developmental milestones (mean age 42.2 months).
  • Included 3117 mothers for regulatory behavior assessment and 2116 for developmental milestones.
  • Maternal Body Mass Index (BMI) and comorbid disorder data were sourced from the Finnish Medical Birth Register.

Main Results:

  • Offspring of overweight/obese mothers exhibited significantly higher levels of regulatory behavior problems.
  • These regulatory behavior problems partially mediated the association between maternal overweight/obesity and multiple domains of child development.
  • No significant association was found between comorbid maternal disorders and offspring regulatory behavior problems.

Conclusions:

  • Offspring regulatory behavior problems have prenatal origins.
  • These behavioral issues partially mediate the impact of maternal overweight/obesity on offspring neurodevelopment.
Abstract

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