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Acinetobacter Infections in Neonates.
Raffaele Zarrilli1, Maria Bagattini2, Eliana Pia Esposito2
1Department of Public Health, University of Naples 'Federico II', Via Pansini 5, 80131, Naples, Italy. rafzarri@unina.it.
Current Infectious Disease Reports
|October 12, 2018
Summary
Multidrug-resistant Acinetobacter species infections are rising in neonatal intensive care units (NICUs). Key risk factors include low birth weight and invasive procedures, necessitating enhanced surveillance.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Multidrug-resistant (MDR) Gram-negative bacteria pose a significant threat to neonates globally.
- Acinetobacter baumannii is a common cause of neonatal infections and outbreaks in neonatal intensive care units (NICUs).
- Limited therapeutic options exacerbate the challenge of treating these infections.
Purpose of the Study:
- To review the epidemiology of Acinetobacter species infections in neonates.
- To identify risk factors associated with Acinetobacter species acquisition in the NICU.
Main Methods:
- Systematic review of published studies on Acinetobacter spp. infections in neonates.
- Analysis of reported incidence, causative species, and identified risk factors.
Main Results:
- Acinetobacter spp. infections are increasing in neonates within NICUs.
- Outbreaks involve both extensively drug-resistant (XDR) A. baumannii and susceptible species.
- Common neonatal infections include bloodstream and respiratory tract infections.
- Identified risk factors for A. baumannii acquisition include low birth weight, prolonged NICU stay, invasive devices (umbilical and central-venous catheters), mechanical ventilation, and prior antibiotic exposure.
Conclusions:
- Surveillance of risk factors for healthcare-associated infections in NICUs is crucial.
- Effective control strategies are needed to combat MDR and XDR A. baumannii infections in neonates.
Keywords:
AcinetobacterAntimicrobial resistanceInfectionNeonatal intensive care unitOutbreakRisk factor analysisMore Related Videos
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