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Updated: Feb 4, 2026

Silencing the Spark: CRISPR/Cas9 Genome Editing in Weakly Electric Fish
Published on: October 27, 2019
Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Therapeutics
Brittany E Givens1,2, Youssef W Naguib1,3, Sean M Geary1
1Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA.
Abstract:
The recent progress in harnessing the efficient and precise method of DNA editing provided by CRISPR/Cas9 is one of the most promising major advances in the field of gene therapy. However, the development of safe and optimally efficient delivery systems for CRISPR/Cas9 elements capable of achieving specific targeting of gene therapy to the location of interest without off-target effects is a primary challenge for clinical therapeutics. Nanoparticles (NPs) provide a promising means to meet such challenges. In this review, we present the most recent advances in developing innovative NP-based delivery systems that efficiently deliver CRISPR/Cas9 constructs and maximize their effectiveness.
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