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The In Situ Sulfidation of Cu2 O by Endogenous H2 S for Colon Cancer Theranostics

Lu An1, Xiaodong Wang1, Xichuan Rui1

  • 1The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China.

Angewandte Chemie (International Ed. in English)
|October 12, 2018
PubMed

Insights

A novel theranostic agent was developed for colon cancer by using copper oxide and hydrogen sulfide (H₂S). This approach enables effective photoacoustic imaging and photothermal therapy, offering a new strategy for colon cancer diagnosis and treatment.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • High concentrations of hydrogen sulfide (H₂S) are linked to colon cancer development.
  • Existing H₂S-triggered theranostic agents for colon cancer are limited.

Purpose of the Study:

  • To develop a novel "turn-on" theranostic agent for colon cancer.
  • To utilize the in situ reaction between copper(I) oxide (Cu₂O) and endogenous H₂S for colon cancer theranostics.

Main Methods:

  • An in situ reaction-based theranostic agent was synthesized using Cu₂O.
  • In vitro and in vivo experiments were conducted to evaluate the agent's efficacy.
  • The agent was activated by endogenous H₂S at colon tumor sites.

Main Results:

  • The developed agent demonstrated excellent photoacoustic imaging capabilities.
  • Effective photothermal therapy was achieved through the in situ reaction.
  • The theranostic method showed high efficiency in both diagnosis and treatment.

Conclusions:

  • A simple and efficient strategy for colon cancer diagnosis and treatment was established.
  • The novel trigger mechanism based on in situ reactions offers a new route for colon cancer theranostics.
  • This work advances the field of targeted cancer therapy and diagnostics.
Keywords:
colon cancercuprous oxideendogenous H2Sin situ reactionstheranostics

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