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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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[Curative Effect of Aprepitant Preventing CINV].

Shasha Guan1, Lisha Zhang1, Diansheng Zhong1

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Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|October 13, 2018
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Summary
This summary is machine-generated.

Aprepitant combined with tropisetron and dexamethasone effectively prevents chemotherapy-induced nausea and vomiting (CINV) in patients undergoing cisplatin treatment, improving their quality of life.

Keywords:
AprepitantCINVCancerCisplatin

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Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Chemotherapy is a primary cancer treatment, but often causes significant nausea and vomiting (CINV).
  • Novel antiemetic drugs like aprepitant offer improved CINV management.
  • This study evaluates a combination therapy for CINV prevention.

Purpose of the Study:

  • To assess the efficacy of aprepitant, tropisetron, and dexamethasone in preventing CINV.
  • To evaluate the antiemetic effect in acute and delayed phases post-cisplatin chemotherapy.

Main Methods:

  • A prospective observational study divided into three phases: whole (0-120h), acute (0-24h), and delayed (24-120h).
  • Primary endpoints included complete response (CR) and complete prevention (CP).

Main Results:

  • Complete response (CR) rates were 86.02% (whole), 89.25% (acute), and 87.1% (delayed).
  • Complete prevention (CP) rates were 46.22% (whole), 83.87% (acute), and 45.16% (delayed).
  • Antiemetic effect showed a significant association with patient age (P=0.008).

Conclusions:

  • Aprepitant, tropisetron, and dexamethasone combination therapy is effective in preventing CINV during cisplatin chemotherapy.
  • This regimen can enhance patient quality of life and chemotherapy adherence.