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High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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Graft-versus-host disease.

David F Moreno1, Joan Cid1

  • 1Unidad de Aféresis y Terapia Celular, ICNU, Servicio de Hemoterapia y Hemostasia, ICMHO; Hospital Clínic, IDIBAPS, Barcelona, España.

Medicina Clinica
|October 13, 2018
PubMed
Summary
This summary is machine-generated.

Graft-versus-host disease (GVHD) is a major complication after stem cell transplants. This review covers GVHD frequency, symptoms, diagnosis, and management strategies.

Keywords:
Enfermedad injerto contra receptorGraft-versus-host diseaseHematopoietic progenitor cell transplantationImmune systemLinfocito TSistema inmuneT cellsTrasplante de progenitores hematopoyéticos

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Area of Science:

  • Immunology
  • Hematology
  • Transplantation Medicine

Background:

  • Graft-versus-host disease (GVHD) is a frequent and potentially fatal complication following allogeneic hematopoietic progenitor cell transplantation.
  • It occurs when donor T cells recognize recipient antigens, leading to immune activation and tissue destruction.
  • GVHD manifests as acute and chronic forms, impacting short-term survival and long-term quality of life.

Purpose of the Study:

  • To review the incidence, clinical features, diagnostic approaches, treatment options, and preventive measures for GVHD.
  • To provide a comprehensive overview of this critical post-transplant complication.

Main Methods:

  • Literature review focusing on frequency, clinical manifestations, diagnosis, treatment, and prevention of GVHD.
  • Synthesis of current knowledge on acute and chronic GVHD.

Main Results:

  • Acute GVHD is a primary cause of mortality in the early post-transplant period.
  • Chronic GVHD contributes significantly to long-term mortality, morbidity, and reduced patient quality of life.
  • GVHD management involves complex strategies for prevention and treatment.

Conclusions:

  • GVHD remains a significant challenge in allogeneic stem cell transplantation.
  • Understanding its multifaceted nature is crucial for improving patient outcomes.
  • Further research into effective prevention and treatment is warranted.