Related Experiment Video
Updated: Feb 4, 2026
05:26
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
9.7K
Muscle squeezing immediately after coronary reperfusion therapy using postconditioning with lactate-enriched blood
Takashi Koyama1, Masahito Munakata1, Takashi Akima1
1Department of Cardiology, Saitama Municipal Hospital, Saitama, Japan.
International Journal of Cardiology
|October 13, 2018
Summary
Postconditioning with lactate-enriched blood (PCLeB) is a novel cardioprotection strategy. Muscle squeezing in the left anterior descending artery after reperfusion is not rare in anterior ST-segment elevation myocardial infarction patients treated with PCLeB.
Area of Science:
- Cardiology
- Cardiovascular Research
- Interventional Cardiology
Background:
- A novel cardioprotection approach, postconditioning with lactate-enriched blood (PCLeB), was previously reported.
- A case of ST-segment elevation myocardial infarction (STEMI) showed coronary artery muscle squeezing after PCLeB reperfusion.
Purpose of the Study:
- To determine the prevalence of coronary artery muscle squeezing after reperfusion in anterior STEMI patients treated with PCLeB.
Main Methods:
- Thirty consecutive anterior STEMI patients were treated with PCLeB, a protocol involving intermittent reperfusion and lactated Ringer's solution injections.
- Immediate post-reperfusion coronary angiography was performed to assess for muscle squeezing.
- Follow-up angiography was conducted in 23 patients.
Main Results:
- Four out of 30 patients exhibited immediate left anterior descending artery (LAD) muscle squeezing post-reperfusion.
- An additional patient showed LAD muscle squeezing on follow-up angiography.
- Myocardial bridging was confirmed in 5 patients; 4 demonstrated immediate muscle squeezing.
Conclusions:
- Coronary artery muscle squeezing following reperfusion therapy is a notable finding in anterior STEMI patients undergoing PCLeB treatment.
- The phenomenon is not rare and may be associated with myocardial bridging.
Related Concept Videos
01:30The Squeeze Theorem
351
Certain mathematical functions exhibit unpredictable or highly variable behavior near specific input values, making direct evaluation of their limits challenging. This complexity may arise from rapid oscillations or irregular patterns that obscure the function’s trend. In such cases, the Squeeze Theorem offers a reliable method for determining limits.According to the Squeeze Theorem, if a function is confined between two other functions near a particular point, and both outer functions...
351
01:48Classification of Skeletal Muscle Fibers
59.5K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.5K
01:21Coronary Circulation
7.3K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
01:26Group Therapy
439
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
439
01:30Coronary Artery Disease I: Introduction
1.1K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K