Related Experiment Video
Updated: Feb 4, 2026

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
Published on: May 10, 2022
Sudden Cardiac Death in Athletes
Andrew D'Silva1, Michael Papadakis1
1St George's University of London, St George's University Hospital Foundation NHS Trust, London, UK.
Sudden cardiac deaths (SCDs) in athletes are often caused by inherited heart conditions in the young or ischemic heart disease in older athletes. Prevention strategies include cardiovascular screening and defibrillators.
Area of Science:
- Sports Cardiology
- Cardiovascular Pathology
- Exercise Physiology
Background:
- Physical activity offers significant health benefits but can trigger sudden cardiac death (SCD) in athletes with underlying conditions.
- SCD in young athletes (≤35 years) is predominantly linked to inherited cardiac diseases.
- Ischemic heart disease is the primary cause of SCD in older athletes.
Purpose of the Study:
- To provide an overview of the epidemiology and causes of SCD in athletes.
- To explore potential prevention strategies for SCD in athletic populations.
- To highlight the importance of accurate post-mortem evaluations and family screening.
Main Methods:
- Review of existing literature on SCD in athletes.
- Analysis of causes of SCD based on age groups (young vs. older athletes).
- Discussion of current and proposed preventative measures.
Main Results:
- Lack of comprehensive registries hinders accurate SCD scale definition in athletes.
- Inconsistent post-mortem evaluations complicate cause determination.
- Inherited cardiac diseases are the main cause in young athletes; ischemic heart disease in older athletes.
Conclusions:
- Cardiovascular screening and automated external defibrillators are key preventative strategies.
- Screening of first-degree relatives is crucial for identifying inherited conditions.
- Improved diagnostic accuracy and registries are needed to reduce SCD in athletes.
Related Concept Videos
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
The Cardiac Cycle
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
Cardiac Cycle
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...

