Related Experiment Video
Updated: Feb 4, 2026

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
Published on: December 9, 2012
Shape optimization of a centrifugal blood pump by coupling CFD with metamodel-assisted genetic algorithm
Behnam Ghadimi1, Amir Nejat2, Seyed Ahmad Nourbakhsh1
1School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Abstract:
A centrifugal blood pump is a common type of pump used as a left ventricular assist device in the medical industries. Therefore, the improvement of the device bio-compatibility to reduce the blood damage and to increase the efficiency has become a major challenge. In the current work, a metamodel-assisted genetic algorithm is employed to simultaneously optimize the impeller and volute geometries of a typical centrifugal blood pump. The overall shape of the base design is inspired from HeartMate3 LVAD, and the main dimensions of the base design including inlet and outlet radius, blade angle distribution, volute cross-section area distribution, etc., are designed in our laboratory. Three different scenarios are investigated using three different objective functions, i.e., (1) hydraulic efficiency, (2) pressure head, and (3) hemolysis index (HI). The results showed that the shape optimized by pump efficiency has also nearly the same level of HI as the shape optimized by HI. Hence, to reduce computation time, one can use efficiency instead of HI as an objective function. However, one must check the HI level after such optimization to see whether it is within the acceptable range of HI for such bio application.
Related Concept Videos
Centrifugation
ATP Driven Pumps III: V-type Pumps
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
ATP Driven Pumps II: P-type Pumps
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
G-protein Coupled Receptors
Centrifugal Force
Molecular Shape and Polarity

