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Updated: Feb 4, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Posterior Vitreous Structures Evaluated by Swept-source Optical Coherence Tomography with En Face Imaging
Jun Woo Park1, Joo Eun Lee1, Kang Yeun Pak2
1Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Swept-source optical coherence tomography (SS-OCT) with en face imaging effectively visualizes posterior vitreous structures like the area of Martegiani and bursa premacularis in healthy eyes. This technique aids in understanding vitreous changes linked to retinal diseases.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- The posterior vitreous is crucial for retinal health.
- Understanding normal vitreous anatomy is essential for diagnosing pathologies.
Purpose of the Study:
- To evaluate posterior vitreous structures using swept-source (SS) optical coherence tomography (OCT) with en face imaging.
- To measure the area and assess the shape of the area of Martegiani (AM) and bursa premacularis (BP) in healthy individuals.
Main Methods:
- Retrospective review of SS-OCT images from healthy individuals.
- Acquisition of high-definition line and 3D scans, with enhanced vitreous visualization.
- En face imaging used for measuring AM and BP areas and shapes.
Main Results:
- 24 eyes from 12 healthy individuals were analyzed.
- Mean AM area was 5.73 ± 0.88 mm² and mean BP area was 18.76 ± 6.95 mm².
- AM was predominantly oval, BP was predominantly round; AM showed consistent contact with the optic disc margins.
Conclusions:
- En face imaging with SS-OCT readily visualizes posterior vitreous structures (AM and BP).
- This method provides insights into normal vitreous configuration.
- Findings may aid in understanding vitreous alterations in retinal diseases.
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