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Low-level laser therapy modulates demyelination in mice.

Katherine Chuere Nunes Duarte1, Thaís Torres Soares1, Angela Maria Paiva Magri1

  • 1Programa Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, UNIFESP, Av. Ana Costa, 95, Santos, SP 11060-001, Brazil; Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, Rua Silva Jardim, 136, Santos, SP 11015-020, Brazil.

Journal of Photochemistry and Photobiology. B, Biology
|October 13, 2018
PubMed
Summary

Low-level laser therapy (LLLT) shows promise for treating demyelinating diseases by improving motor function and reducing myelin loss. This therapy may also support remyelination and modulate neuroinflammation.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Demyelinating diseases lack effective treatments, creating a need for novel therapeutic strategies.
  • Low-level laser therapy (LLLT) has demonstrated neuroprotective and anti-inflammatory effects in various central and peripheral nervous system models.

Purpose of the Study:

  • To investigate the efficacy of LLLT in a mouse model of cuprizone-induced demyelination.
  • To assess LLLT's impact on motor function, demyelination, oligodendrocyte precursor cells, and neuroinflammation.

Main Methods:

  • Mice received a cuprizone diet to induce demyelination, with some groups receiving transcranial laser irradiation.
  • Motor coordination was evaluated using the rotarod test.
  • Histopathological and immunohistochemical analyses were performed on brain tissue, alongside serum toxicity testing.

Main Results:

  • LLLT treatment improved motor performance in demyelinated mice.
  • Laser therapy attenuated demyelination and increased oligodendrocyte precursor cell numbers.
  • LLLT modulated microglial and astrocyte activation and reduced cuprizone-induced toxicity.

Conclusions:

  • LLLT demonstrates potential as a therapeutic approach for demyelinating diseases.
  • Further research is warranted to fully elucidate LLLT's mechanisms and clinical applicability in remyelination.