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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
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Hormones Secreted by the Stomach01:25

Hormones Secreted by the Stomach

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Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
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Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

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Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
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Tubular Reabsorption and Secretion01:28

Tubular Reabsorption and Secretion

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Tubular secretion and reabsorption are two critical processes in the nephron tubule of the kidneys. When the fluid filtered from the glomerulus enters the proximal convoluted tubule, it is referred to as filtrate, and its composition changes due to tubular reabsorption and secretion.
Tubular reabsorption is a selective process that starts when the filtrate enters the proximal tubules. It involves substances traveling through the transcellular route (through the tubule cell and peritubular...
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Related Experiment Video

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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

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Steroid secretion in healthy aging.

Serena Fiacco1, Andreas Walther2, Ulrike Ehlert1

  • 1Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland; URPP Dynamics of Healthy Aging Research Priority Program, University of Zurich, Zurich, Switzerland.

Psychoneuroendocrinology
|October 14, 2018
PubMed
Summary
This summary is machine-generated.

Healthy aging is a priority, with hormonal changes affecting older adults. Lifestyle interventions like exercise can mitigate these changes and promote well-being.

Keywords:
Body compositionCognitionHealthy agingMoodSexual functionSteroid hormones

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Area of Science:

  • Gerontology and Endocrinology
  • Physiology of Aging

Background:

  • Increased lifespan leads to higher chronic disease rates, impacting quality of life and societal costs.
  • Healthy aging is a critical healthcare focus, involving physical and mental well-being.
  • Age-related hormonal shifts present challenges to maintaining health in later life.

Purpose of the Study:

  • To define a phenotype for healthy aging using body composition, cognition, mood, and sexual function.
  • To review age-related changes in sex hormones and glucocorticoids in men and women.
  • To explore the impact of these hormonal alterations on healthy aging.

Main Methods:

  • Literature review of age-related hormonal changes.
  • Analysis of hormonal patterns in men and women.
  • Examination of mechanisms underlying steroid alterations.

Main Results:

  • Significant age-related alterations in sex hormones and glucocorticoids occur, with distinct patterns in men and women.
  • These hormonal changes pose challenges to healthy aging.
  • Hormonal treatment is advised only for deficiency symptoms; lifestyle factors are key.

Conclusions:

  • Healthy aging requires addressing physical and mental adaptations, including hormonal changes.
  • Lifestyle interventions, such as physical exercise, are effective preventive strategies.
  • Maintaining well-being involves understanding and managing age-related steroid alterations.