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Related Experiment Videos

Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumors in Bronchus.

Jun Chen1, Tao Yuan1, Xiao Liu1

  • 1Department of Medical imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

The American Journal of the Medical Sciences
|October 14, 2018
PubMed
Summary
This summary is machine-generated.

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Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET) is a rare malignant soft tissue tumor. This case report details a primary bronchial ES/pPNET successfully treated with surgery and chemotherapy.

Area of Science:

  • Oncology
  • Pulmonary Medicine
  • Pathology

Background:

  • Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET) are rare malignant soft tissue tumors characterized by small, undifferentiated neuroectodermal cells.
  • Primary ES/pPNET of the trachea-bronchial tree is exceptionally uncommon, with most pulmonary occurrences being metastatic.
  • This report focuses on a unique case of primary ES/pPNET originating in the left basal trunk bronchus.

Observation:

  • A 30-year-old male presented with a 10-day history of irritable cough and fever.
  • Imaging revealed a 60 mm tumor in the left basal trunk bronchus, extending into the left lower lobe, with no evidence of distant metastases.
  • Histopathological examination confirmed ES/pPNET, showing diffuse round cell proliferation, Flexner-Wintersteiner rosettes, and positive CD99 staining.
Keywords:
BronchusEwing sarcomaPeripheral primitive neuroectodermal tumor

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Findings:

  • The patient underwent a left lower lobectomy followed by adjuvant chemotherapy.
  • The treatment resulted in a successful outcome, with the patient remaining disease-free for approximately 18 months post-treatment.
  • This case underscores the importance of considering ES/pPNET in the differential diagnosis of bronchial tumors.

Implications:

  • Primary bronchial ES/pPNET, though rare, is a treatable condition.
  • Early diagnosis and multimodal treatment, including surgery and chemotherapy, can lead to favorable prognoses.
  • This case contributes to the limited literature on primary tracheal-bronchial ES/pPNET, emphasizing its potential occurrence and successful management.