Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

985
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
985
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

2.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.0K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

636
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
636
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

994
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
994
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.0K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.0K
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

560
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
560

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance-Based Usability of Medication Adherence Technologies Among Older Adults With Diverse Capabilities: Quantitative Study.

JMIR aging·2026
Same author

Principles and Outcomes of Compartmental Resection in Upper Gingivobuccal Cancers.

Oral and maxillofacial surgery clinics of North America·2026
Same author

Advances in Reconstructive Surgery for Gingivobuccal Cancers.

Oral and maxillofacial surgery clinics of North America·2026
Same author

Designing a computerized decision support system for asthma chronic disease management in community pharmacies.

International journal of clinical pharmacy·2026
Same author

Personalized Predictive Model to Predict Subtask Success of Medication Adherence Technologies for Older Adults With Diverse Capabilities: Development and Internal Validation Study.

JMIR aging·2026
Same author

How pharmacy education and practice cultivate researchers: the Canadian experience.

The International journal of pharmacy practice·2026

Related Experiment Video

Updated: Feb 4, 2026

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices
07:27

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Published on: January 31, 2019

10.3K

Demystifying serotonin syndrome (or serotonin toxicity).

Ai-Leng Foong1, Kelly A Grindrod2, Tejal Patel3

  • 1Completed her Doctor of Pharmacy degree at the University of Waterloo School of Pharmacy in Ontario.

Canadian Family Physician Medecin De Famille Canadien
|October 14, 2018
PubMed
Summary

Serotonin toxicity, or serotonin syndrome, is a drug-induced condition. Primary care providers can prevent and identify serotonin toxicity by recognizing symptoms and monitoring patients on serotonin-elevating medications.

More Related Videos

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

9.3K
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.6K

Related Experiment Videos

Last Updated: Feb 4, 2026

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices
07:27

Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices

Published on: January 31, 2019

10.3K
Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

9.3K
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.6K

Area of Science:

  • Pharmacology
  • Clinical Toxicology
  • Neuroscience

Background:

  • Serotonin toxicity arises from excessive serotonin in brain synapses.
  • While severe cases requiring hospitalization are rare, patients exhibit neuromuscular, autonomic, and mental status changes.
  • Mild cases are generally not fatal.

Purpose of the Study:

  • To review symptoms and causative drugs of serotonin toxicity (serotonin syndrome).
  • To examine the mechanisms of action for drugs causing serotonin toxicity.
  • To provide primary care providers with strategies for prevention and identification.

Main Methods:

  • Searched PubMed and Google Scholar for articles on serotonin toxicity, causes, and differential diagnosis.
  • Utilized search terms including "serotonin syndrome," drug classes, and diagnostic terms.
  • Consulted experts in psychiatric medicine, pharmacy, pharmacology, and toxicology.

Main Results:

  • Serotonin toxicity is drug-induced, resulting from elevated synaptic serotonin.
  • Commonly implicated drugs include monoamine oxidase inhibitors, serotonin reuptake inhibitors, and serotonin releasers.
  • Combinations of drugs, particularly MAOIs with SSRIs or SNRIs, pose the highest risk.

Conclusions:

  • Family physicians are crucial in identifying and preventing serotonin syndrome.
  • Patient education on recognizing symptoms and ongoing monitoring are key strategies.
  • Early identification and intervention by primary care providers can improve patient outcomes.