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Updated: Feb 4, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.9K
[Immunotherapy in castration resistant prostate cancer.]
Bernardino Miñana López1, Felipe Villacampa Aubá1, Fernando Ramón de Fata Chillón1
1Departamento de Urología. Clínica Universidad de Navarra. Madrid/Pamplona. España.
Archivos Espanoles De Urologia
|October 16, 2018
Summary
Immunotherapy for castration resistant prostate cancer (CRPC) shows limited efficacy. Combination strategies and identifying predictive biomarkers are crucial for improving patient outcomes and potentially chronifying the disease.
Area of Science:
- Oncology
- Immunology
- Urology
Background:
- Castration resistant prostate cancer (CRPC) presents characteristics suggesting immunotherapy could be effective.
- Current immunotherapeutic strategies include vaccines and immune checkpoint inhibitors.
Purpose of the Study:
- To review the role and efficacy of immunotherapy in castration resistant prostate cancer.
- To identify limitations and future directions for immunotherapy in CRPC treatment.
Main Methods:
- Review of existing literature on immunotherapy in CRPC.
- Analysis of clinical trial data for vaccines and immune checkpoint inhibitors.
- Evaluation of combination strategies with other cancer therapies.
Main Results:
- Immunotherapy in CRPC demonstrates limited and heterogeneous activity with low objective response rates.
- Sipuleucel T is the only vaccine to show an overall survival increase in specific patient groups.
- Progression-free survival is not typically improved due to immunotherapy's mechanism of action.
- Best responses to isolated immunotherapy are seen in patients with low tumor burden.
Conclusions:
- Immunotherapy's clinical application in CRPC is limited, necessitating the identification of predictive biomarkers.
- Combination therapies, particularly with agents that increase cell lysis and antigen exposure, hold the most promise.
- Future strategies should focus on combining immunotherapy with other active treatments to achieve disease chronification.
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