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Updated: Feb 4, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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[Radium 223 in castration resistant prostate cancer.]
Ana Loizaga-Iriarte1, Isabel Camargo Ibargarai2, Nerea Senarriaga-Ruiz de la Illa2
1Hospital Universitario Basurto. Bilbao. España.CIBERONC.España.
Archivos Espanoles De Urologia
|October 16, 2018
Summary
Radium 223 therapy, an alpha emitter, significantly improves survival for castration-resistant prostate cancer patients with bone metastases. This bone-targeted treatment also reduces skeletal events and has manageable side effects.
Area of Science:
- Oncology
- Radiopharmaceutical Therapy
- Prostate Cancer Research
Background:
- Castration-resistant prostate cancer (CRPC) with bone metastases presents significant challenges.
- Bone metastases in CRPC lead to pain, skeletal events, and reduced survival.
- Existing treatments often have limited efficacy or significant toxicity.
Purpose of the Study:
- To analyze evidence for Radium 223 dichloride (Ra-223) in CRPC patients with bone metastases.
- To evaluate the efficacy and safety of Ra-223 based on pivotal trials and real-world data.
- To explore ongoing research involving Ra-223 in combination therapies.
Main Methods:
- Review of the pivotal ALSYMPCA study for Ra-223 drug approval.
- Analysis of post-approval data and real-world evidence for Ra-223.
- Literature search for ongoing clinical trials of Ra-223 in CRPC.
Main Results:
- The ALSYMPCA study demonstrated a significant overall survival benefit for Ra-223 (3.6 months median increase).
- Ra-223 reduced the risk of death by 30% and improved survival rates at 36 months (46%).
- Ra-223 positively impacted symptomatic skeletal events and bone markers, confirming efficacy in bone metastases.
Conclusions:
- Radium 223 is the first bone-targeted therapy to significantly improve overall survival in CRPC.
- Ra-223 prolongs time to first skeletal event and prostate-specific antigen (PSA) increase.
- Ra-223 exhibits a manageable safety profile, with fewer adverse effects than placebo in the ALSYMPCA trial.
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