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Related Concept Videos

Diffusion01:12

Diffusion

218.6K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

Diffusion

6.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Facilitated Diffusion01:16

Facilitated Diffusion

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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

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Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.3K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

5.6K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

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Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
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Related Experiment Video

Updated: Feb 3, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

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Compressed Sensing Diffusion Spectrum Imaging for Accelerated Diffusion Microstructure MRI in Long-Term Population

Alexandra Tobisch1,2, Rüdiger Stirnberg1, Robbert L Harms3

  • 1German Center for Neurodegenerative Diseases, Bonn, Germany.

Frontiers in Neuroscience
|October 16, 2018
PubMed
Summary
This summary is machine-generated.

Compressed sensing diffusion spectrum imaging (CS-DSI) shows comparable performance to established 3-shell HARDI for brain microstructure mapping in population studies. This advanced protocol is suitable for long-term, high-throughput neuroimaging research.

Keywords:
compressed sensingdiffusion MRIdiffusion spectrum imagingmicrostructuremulti-shell HARDIpopulation imaging

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Area of Science:

  • Neuroimaging
  • Diffusion Magnetic Resonance Imaging (dMRI)
  • Biomedical Engineering

Background:

  • Diffusion MRI is crucial for mapping brain microstructure in population studies.
  • Longitudinal studies require dMRI protocols with reliability and future analysis potential.
  • Advanced dMRI acquisition strategies are now feasible with new MRI hardware.

Purpose of the Study:

  • To evaluate compressed sensing diffusion spectrum imaging (CS-DSI) for high-resolution dMRI in long-term population studies.
  • To assess the comparability of CS-DSI with 3-shell high angular resolution diffusion imaging (HARDI) for microstructural analysis.

Main Methods:

  • A pilot study involving 20 subjects was conducted.
  • CS-DSI and 3-shell HARDI protocols were applied.
  • Advanced diffusion processing techniques were used, including parameter mapping and fiber tracking.

Main Results:

  • CS-DSI demonstrated comparable performance to 3-shell HARDI in estimating diffusion and microstructural parameters.
  • Both protocols yielded similar results for fiber orientation estimation and local fiber tracking.
  • CS-DSI offers high radial and angular resolution, suitable for high b-value analyses.

Conclusions:

  • CS-DSI is a viable advanced imaging protocol for microstructure dMRI in long-term, high-throughput population studies.
  • CS-DSI is well-suited for advanced analyses requiring high b-value data, such as CHARMED modeling.