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Updated: Feb 3, 2026

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
An exploratory study on the effect of daily fruits and vegetable juice on human gut microbiota
Yoon Jin Choi1,2, Dong Ho Lee1,3, Hyun Soo Kim1
11Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam, Gyeonggi-do 13620 South Korea.
Abstract:
In order to evaluate the effect of daily consumption of fruit and vegetable juice on the human intestinal microbial community, we compared changes in the gut microbiota and extracellular vesicles in human feces and bowel, and skin symptoms at the baseline and 3 weeks post juice consumption of 22 participants. After 3 weeks of juice consumption, a significant increase in the richness of microbiota (α-diversity, P < 0.05) was observed. It was accompanied by an abundance in Faecalibacterium (bacterial: from 1.62 ± 0.80% to 2.14 ± 0.72% and extra vesicle: 2.49 ± 1.49% to 6.06 ± 3.07%; P < 0.05 in all cases). At the end of the study period, there were reductions in body weight regardless of sex (P < 0.05) and improvements of the symptoms including diarrhea, constipation, fatigue, and skin problems. Eating fruits and vegetables could help modulate the profile of the fecal microbiota and alleviate bowel and skin troubles, and fatigue.
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