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Related Experiment Video

Updated: Feb 3, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Fiber bundle shifting endomicroscopy for high-resolution imaging.

Khushi Vyas¹, Michael Hughes², Bruno Gil Rosa¹

¹Hamlyn Centre for Robotic Surgery, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Biomedical Optics Express

|October 16, 2018

Summary

This study introduces a new piezoelectric transducer (PZT) based endomicroscopy system. It enhances spatial resolution for clearer in vivo cellular imaging in minimally-invasive procedures.

Keywords:

(100.3020) Image reconstruction-restoration (110.0180) Microscopy (170.2150) Endoscopic imaging

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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

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Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

Area of Science:

Biomedical Engineering
Optical Imaging
Microscopy

Background:

Flexible endomicroscopes are crucial for in vivo imaging in minimally-invasive procedures.
Current systems face limitations in spatial resolution due to fiber bundle under-sampling, hindering visualization of small cellular features.

Purpose of the Study:

To develop a compact, rapid piezoelectric transducer (PZT) based endomicroscopy system.
To achieve super-resolution (SR) image restoration from pixelation-limited images using computational methods.

Main Methods:

A miniaturized PZT tube actuates the fiber bundle behind a GRIN micro-lens.
A Delaunay triangulation algorithm reconstructs the enhanced SR image.
A line-scan confocal laser endomicroscope system operates at 120 fps raw frame rate for real-time imaging.

Main Results:

The system achieves up to 2x spatial resolution improvement.
Demonstrated a field of view of 350 µm at a net frame rate of 30 fps.
Resolution enhancement was validated using phantoms and ex vivo human breast tissue imaging.

Conclusions:

The PZT-based bundle-shifting endomicroscopy system offers enhanced spatial resolution for cellular imaging.
This technology enables real-time, high-resolution in vivo visualization in endoscopic applications.
The system shows promise for improved diagnostic capabilities in minimally-invasive procedures.