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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

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Inhibitory effects of Schisandrin B on human prostate cancer cells

Moussa Ide Nasser1, Tingyu Han1, Salah Adlat1

  • 1Colleges of Life Science and Technology, Dalian University, Dalian Economical Technological Development Zone, Liaoning 116622, P.R. China.

Oncology Reports
|October 16, 2018
PubMed

Insights

Schisandrin B (Sch B) effectively inhibits prostate cancer cell growth and induces cancer cell death. This natural compound shows potential as a novel therapeutic agent for prostate cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Prostate cancer remains a significant global health concern.
  • Understanding the molecular mechanisms of prostate cancer is crucial for developing effective treatments.
  • Schisandrin B (Sch B) is a natural compound with potential anti-cancer properties.

Purpose of the Study:

  • To comprehensively examine the molecular mechanisms by which Schisandrin B (Sch B) induces cytotoxicity in human prostate cancer cells.
  • To investigate the effects of Sch B on prostate cancer cell proliferation, apoptosis, and cell cycle progression.
  • To elucidate the signaling pathways involved in Sch B-induced apoptosis in prostate cancer cells.

Main Methods:

  • Flow cytometry was used to analyze cell apoptosis and cell cycle arrest.
  • Western blot analysis was employed to assess protein expression and phosphorylation levels.
  • Real-time PCR was utilized to investigate gene expression related to apoptosis and signaling pathways.

Main Results:

  • Schisandrin B (Sch B) inhibited proliferation and induced apoptosis and S-phase arrest in DU145 and LNCaP prostate cancer cells.
  • Sch B-induced apoptosis in LNCaP cells was linked to oxidative stress generation.
  • Sch B treatment inhibited androgen receptor signaling and the phosphorylation of PI3K/AKT and STAT3/JAK2 pathways.

Conclusions:

  • Schisandrin B (Sch B) exhibits significant antitumor effects against prostate cancer cells.
  • The molecular mechanisms involve oxidative stress, androgen receptor inhibition, and modulation of PI3K/AKT and STAT3/JAK2 pathways.
  • Schisandrin B (Sch B) holds potential as a pharmacological agent for prostate cancer treatment.

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