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Updated: Feb 3, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

EWASdb: epigenome-wide association study database.

Di Liu^1,2, Linna Zhao^1,2, Zhaoyang Wang^1,2

¹College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

Nucleic Acids Research

|October 16, 2018

Summary

This summary is machine-generated.

The EWASdb is a new database archiving epigenome-wide association study (EWAS) results for DNA methylation. This resource aids research into the molecular basis of diseases and phenotypes.

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Published on: July 27, 2021

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Area of Science:

Epigenetics
Genomics
Bioinformatics

Background:

DNA methylation is a key epigenetic modification crucial for understanding disease mechanisms.
Epigenome-wide association studies (EWAS) systematically identify epigenetic variants linked to diseases and phenotypes.
A comprehensive database for archiving EWAS results is currently lacking.

Purpose of the Study:

To develop and present EWASdb, the first comprehensive database archiving DNA methylation association results from EWAS.
To provide a centralized resource for researchers investigating the epigenetic basis of diseases and phenotypes.

Main Methods:

Curated data from 1319 EWAS associated with 302 diseases/phenotypes.
Inclusion of three types of EWAS results: single marker, KEGG pathway, and Gene Ontology (GO) category.
Database version 1.0, updated through July 2018.

Main Results:

EWASdb stores epigenetic association results from DNA methylation studies.
The database currently contains 1319 EWAS covering 302 diseases/phenotypes.
EWASdb has been accessed by researchers from 43 countries.

Conclusions:

EWASdb serves as a valuable resource for epigenetic research in diseases and phenotypes.
The database has potential for clinical applications in understanding disease molecular basis.
EWASdb is freely accessible online for global research communities.