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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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Published on: October 12, 2012

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New anticoagulants, reversal agents, and clinical considerations for perioperative practice

Brendon M Hart1, Stephane M Ferrell2, Mark W Motejunas3

  • 1Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.

Best Practice & Research. Clinical Anaesthesiology
|October 17, 2018
PubMed

Insights

New anticoagulant and antiplatelet drugs impact perioperative care, especially with regional anesthesia. Understanding bleeding risks and new reversal agents is crucial for safe patient management.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • New anticoagulant and antiplatelet drugs are increasingly used, posing challenges for perioperative management.
  • Regional anesthesia requires careful consideration of antithrombotic agents due to bleeding risks.
  • Existing antithrombotic medications carry an inherent risk of increased bleeding.

Purpose of the Study:

  • To review new anticoagulant and antiplatelet drugs impacting perioperative care.
  • To discuss the implications of these agents in regional anesthesia.
  • To highlight the importance of understanding drug categories, reversal agents, and procedural guidelines.

Main Methods:

  • Literature review of new antithrombotic agents.
  • Analysis of drug categories: antiplatelet, anticoagulant, and thrombolytic.
  • Examination of guidelines for procedural timing after drug cessation, including American Society of Regional Anesthesia and Pain Medicine recommendations.

Main Results:

  • New antithrombotic drugs present unique challenges and risks in perioperative settings.
  • Specific guidelines exist for managing patients on these medications undergoing procedures.
  • New reversal agents are becoming available to manage bleeding complications.

Conclusions:

  • Safe perioperative care requires a thorough understanding of new antithrombotic agents and their management.
  • Adherence to established guidelines and the use of reversal agents are key to mitigating risks.
  • Further research and updated protocols are needed to optimize patient safety in regional anesthesia with novel anticoagulants.
Keywords:
anticoagulantsantiplatelet drugsperioperative careregional anesthesiareversal agents

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