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Related Experiment Video

Updated: Feb 3, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

Phenotyping of Mouse Models with OCT.

G Alex Ochakovski¹, M Dominik Fischer²

¹Centre for Ophthalmology, University Eye Hospital, University of Tuebingen, Tuebingen, Germany.

Methods in Molecular Biology (Clifton, N.J.)

|October 17, 2018

Summary

Optical coherence tomography (OCT) enables noninvasive retinal imaging in mice, providing virtual cross sections. This technique supports timeline analyses for dynamic changes, reducing animal use in studies.

Keywords:

Animal models Confocal scanning laser ophthalmoscopy Morphology Optical coherence tomography Retina

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Area of Science:

Ophthalmology
Biomedical Imaging
Animal Models

Background:

Optical coherence tomography (OCT) is crucial for noninvasive retinal imaging.
Small animal models, like mice, are vital for preclinical research.
Histomorphometric data provides structural information but is invasive.

Purpose of the Study:

To highlight the utility of OCT for noninvasive retinal imaging in mouse models.
To emphasize OCT's ability to capture dynamic changes over time.
To demonstrate OCT's potential to reduce animal numbers in research.

Main Methods:

Utilizing OCT for in vivo retinal imaging in mice.
Acquiring serial cross-sectional images.
Correlating OCT data with histomorphometric findings.

Main Results:

OCT provides high-resolution virtual cross sections of the mouse retina.
Iterative OCT measurements allow for timeline analysis of retinal changes.
OCT data correlates well with traditional histomorphometric analysis.

Conclusions:

OCT is an invaluable tool for noninvasive, longitudinal retinal studies in mice.
The technique facilitates the detection of dynamic retinal processes.
OCT can significantly reduce the number of animals required for research studies.