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Review and Preview

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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Review and Preview

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

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Crohn's disease
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Immunodeficiency Diseases

Immunodeficiency Diseases

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Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

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Related Experiment Video

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Selenium and Autoimmune Diseases: A Review Article.

Maryam Sahebari¹, Zahra Rezaieyazdi¹, Mandana Khodashahi¹

¹Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Current Rheumatology Reviews

|October 17, 2018

Summary

Low selenium levels are common in autoimmune diseases, potentially increasing inflammation. Supplementation with selenium, particularly L-selenomethionine, may improve clinical symptoms and survival in patients with these conditions.

Keywords:

SLE Selenium autoimmune diseases collagen vascular diseases rheumatoid arthritis trace elements.

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Area of Science:

Biochemistry
Immunology
Nutritional Science

Background:

Selenium is a vital trace element impacting human biology.
Deficiency in trace elements, including selenium, is frequently observed in autoimmune diseases.
Selenium's role in mitigating reactive oxygen species and inflammation suggests its importance in autoimmune conditions.

Purpose of the Study:

To systematically review the role of selenium in autoimmune rheumatic diseases.
To evaluate the association between selenium levels and the pathogenesis and management of these conditions.

Main Methods:

A systematic review of studies indexed in PubMed, Scopus, Science Direct, and Google Scholar.
Inclusion of studies on selenium use without limitations on preparation or administration, excluding non-English articles, non-selenium treatments, animal models, and studies with insufficient data.
Keywords included "selenium" combined with various autoimmune rheumatic diseases such as scleroderma, Sjögren syndrome, systemic lupus erythematosus, and rheumatoid arthritis.

Main Results:

Out of 312 initial articles, 32 were included in the review.
A majority of studies indicated lower selenium levels in patients with collagen vascular diseases.
Treatment with L-selenomethionine demonstrated improvement in clinical symptoms for these patients compared to controls.

Conclusions:

Reduced serum selenium levels in autoimmune disease patients may be a risk factor for inflammation and autoimmunity.
Adequate selenium intake can aid in managing complications and potentially improve survival in autoimmune diseases due to its anti-inflammatory properties.
Selenium's role warrants consideration in nutritional interventions for autoimmune disease management.