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Updated: Feb 3, 2026

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Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment
Published on: February 23, 2024
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Cleft Palates and Occlusal Outcomes in Pierre Robin Sequence
Julie Bao Anh Do1, Audrey Bellerive2, Anne-Sophie Julien3
11 Department of Otolaryngology-Head and Neck Surgery, Université Laval, Quebec City, Quebec, Canada.
Summary
Children with Pierre Robin sequence (PRS) often develop Class III malocclusion, with larger clefts linked to mandibular retrusion. This highlights the need to consider early airway management strategies.
Area of Science:
- Craniofacial development
- Pediatric dentistry
- Orthodontics
Background:
- Pierre Robin sequence (PRS) is a congenital condition affecting craniofacial development.
- Conservative management of PRS can impact dental occlusion and facial growth.
- Understanding cephalometric characteristics is crucial for predicting outcomes.
Purpose of the Study:
- To evaluate dental occlusion and lateral cephalometry in children with conservatively treated PRS.
- To determine associations between cleft palate measurements and cephalometric findings.
- To inform early management strategies for PRS patients.
Main Methods:
- Retrospective cohort study of 22 PRS patients.
- Dental occlusion and lateral cephalometry assessed at age 6.
- Preoperative cleft palate measurements collected.
- Statistical analysis included logistic regression and Spearman's correlation.
Main Results:
- 41% of patients exhibited Class III malocclusion.
- Bimaxillary hypoplasia and hyperdivergency were common.
- Increased anterior mandibular growth contributed to Class III malocclusion (SNB angle difference significant, P = .04).
- Larger cleft width correlated with mandibular retrusion (rs = -0.5, P = .02).
Conclusions:
- The high prevalence of Class III malocclusion in conservatively treated PRS warrants consideration for initial airway management.
- Early mandibular advancement may influence long-term outcomes.
- Further research is needed to determine the impact of early interventions.
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