Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphism and gene conversion in mouse alpha-globin haplotypes.

M A Erhart, K Piller, S Weaver

    Genetics
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

    Physical review letters·2024
    Same author

    Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

    Physical review letters·2022
    Same author

    Assembly of high-areal-density deuterium-tritium fuel from indirectly driven cryogenic implosions.

    Physical review letters·2012
    Same author

    Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome.

    Neurology·2011
    Same author

    Demonstration of ignition radiation temperatures in indirect-drive inertial confinement fusion hohlraums.

    Physical review letters·2011
    Same author

    Wide angular aperture holograms in photorefractive crystals by the use of orthogonally polarized write and read beams.

    Applied optics·2010
    Same journal

    Coexistence of piRNA and KZFP defense systems: Evolutionary dynamics of layered defense against transposable elements.

    Genetics·2026
    Same journal

    Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase.

    Genetics·2026
    Same journal

    Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

    Genetics·2026
    Same journal

    Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

    Genetics·2026
    Same journal

    Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

    Genetics·2026
    Same journal

    Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

    Genetics·2026
    See all related articles

    Gene conversion events shaped mouse alpha-globin evolution, leading to sequence identity and distinct protein variants. These findings highlight the dynamic nature of globin gene family evolution.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • Alpha-globin genes are crucial for oxygen transport.
    • Understanding gene evolution provides insights into molecular mechanisms and disease.
    • Mouse models are essential for studying mammalian gene function and evolution.

    Purpose of the Study:

    • To characterize alpha-globin haplotypes in Mus domesticus.
    • To determine the complete nucleotide sequences of alpha-globin genes.
    • To investigate the role of gene conversion in alpha-globin evolution.

    Main Methods:

    • Cloning and characterization of alpha-globin haplotypes from inbred mouse strains.
    • Determination of complete nucleotide sequences of six alpha-globin genes.

    Related Experiment Videos

  • Comparative sequence analysis to identify gene conversion events and nucleotide substitutions.

    • Main Results:

    • Three distinct alpha-globin haplotypes were identified in Mus domesticus.
    • Recurrent gene conversion events, both within and between haplotypes, were inferred from sequence analysis.
    • Both coding and noncoding DNA segments were involved in gene conversion.
    • Some genes maintained sequence identity and encoded identical polypeptides, while others accumulated changes leading to distinct alpha-globins.
    • Evidence suggests positive selection may have acted on advantageous mutations in one haplotype.

    Conclusions:

    • Gene conversion is a significant evolutionary mechanism shaping the alpha-globin gene family in mice.
    • The interplay of gene conversion and mutation generates both conserved and divergent alpha-globin sequences.
    • These findings contribute to our understanding of gene family evolution and the generation of protein diversity.