Related Experiment Video
Updated: Feb 3, 2026
09:56
Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
Published on: April 30, 2019
9.6K
Zebrafish: Speeding Up the Cancer Drug Discovery Process
Patricia Letrado1,2, Irene de Miguel2, Iranzu Lamberto1
1Ikan Biotech SL, The Zebrafish Lab Department, Centro Europeo de Empresas e Innovación de Navarra (CEIN), Noain, Spain.
Cancer Research
|October 18, 2018
Summary
Zebrafish (Danio rerio) models offer a powerful in vivo approach for cancer drug discovery. This review details their use in tumor induction, progression monitoring, and compound administration, supported by 355 case studies.
Area of Science:
- Comparative Oncology
- Translational Cancer Research
- Aquatic Animal Models
Background:
- Zebrafish (Danio rerio) are increasingly utilized as a versatile in vivo model for studying human cancers.
- Their genetic tractability and rapid development facilitate cancer research.
Purpose of the Study:
- To provide a comprehensive review of zebrafish applications in cancer drug discovery.
- To analyze existing case studies and explore future directions for zebrafish in oncology.
Main Methods:
- Overview of methods for inducing malignant tumors in zebrafish.
- Description of techniques for monitoring cancer progression in vivo.
- Strategies for compound administration and screening in zebrafish models.
Main Results:
- Compilation and analysis of 355 case studies demonstrating the impact of zebrafish models.
- Coverage of diverse cancer types and drug discovery scenarios.
- Identification of zebrafish models' potential as prognostic tools.
Conclusions:
- Zebrafish models are crucial for advancing cancer drug discovery and development.
- Future research should leverage zebrafish for personalized medicine and prognostic applications.
- This model system holds significant promise for accelerating the identification of novel cancer therapeutics.
Related Concept Videos
01:26Drug Discovery: Overview
11.6K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
11.6K
01:08Speed of Sound in Gases
4.1K
The speed of sound in a gaseous medium depends on various factors. Since gases constitute molecules that are free to move, they are highly compressible. Hence, sound waves travel slowly through gases. Thermodynamics helps us understand the relationship between pressure, volume, and temperature of gases, thus, the speed of sound in an ideal gas can be determined using the laws of thermodynamics. At the same time, Newton's laws of motion and the continuity equation of fluid dynamics also come...
4.1K
01:13Speed of a Transverse Wave
4.0K
The speed of a wave depends on the characteristics of the medium. For example, in the case of a guitar, the strings vibrate to produce the sound. The speed of the waves on the strings and the wavelength determine the frequency of the sound produced. The strings on a guitar have different thicknesses but may be made of similar material. They have different linear densities, and the linear density is defined as the mass per length.
One of the key properties of any wave is the wave speed. Light...
One of the key properties of any wave is the wave speed. Light...
4.0K
01:27Distribution of Molecular Speeds
5.5K
The motion of molecules in a gas is random in magnitude and direction for individual molecules, but a gas of many molecules has a predictable distribution of molecular speeds. This predictable distribution of molecular speeds is known as the Maxwell-Boltzmann distribution. The distribution of molecular speeds in liquids is comparable to that of gases but not identical and can help to understand the phenomenon of the boiling and vapor pressure of a liquid. Consider that a molecule requires a...
5.5K
01:18Drag Force and Terminal Speed
3.4K
An interesting force in everyday life is the force of drag on an object when it is moving in a fluid. Like friction, the drag force always opposes the motion of an object. Unlike simple friction, the drag force is proportional to some function of the velocity of the object in that fluid. This functionality is complicated and depends upon the shape of the object, its size, its velocity, and the fluid it is in. For most large objects, such as cyclists, cars, and baseballs, that are not moving too...
3.4K
01:09Deriving the Speed of Sound in a Liquid
965
As with waves on a string, the speed of sound or a mechanical wave in a fluid depends on the fluid's elastic modulus and inertia. The two relevant physical quantities are the bulk modulus and the density of the material. Indeed, it turns out that the relationship between speed and the bulk modulus and density in fluids is the same as that between the speed and the Young's modulus and density in solids.
The speed of sound in fluids can be derived by considering a mechanical wave...
The speed of sound in fluids can be derived by considering a mechanical wave...
965