Related Experiment Video
Updated: Feb 3, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
Fat Versus Carbohydrate-Based Energy-Restricted Diets for Weight Loss in Patients With Type 2 Diabetes
Osama Hamdy1, Mhd Wael Tasabehji2, Taha Elseaidy2
1Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA, 02215, USA. Osama.hamdy@Joslin.harvard.edu.
Purpose Of Review:
The prevalence of combined obesity and diabetes has increased dramatically in the last few decades. Although medical and surgical weight management are variably effective in addressing this epidemic, it is essential to parallel these strategies with a hypocaloric diet comprising the appropriate macronutrient composition to induce weight loss, enhance glycemic control, and improve cardiovascular risk factors. This review reports the current evidence of the role of carbohydrates and fat-based diets for weight management in patients with combined type 2 diabetes (T2D) and obesity.
Recent Findings:
Low-carbohydrate diets were shown to decrease postprandial glucose levels whereas high-carbohydrate, low-fat diets are considered cardio-protective. A diet with an optimal macronutrient composition remains uncertain for patients with combined T2D and obesity. Further research is still needed to define the best dietary composition that achieves the maximum benefits on weight management, glycemic control, and cardiovascular risk factors.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Energy Losses in Transformers
There are four main reasons for energy losses in transformers.
The first cause can be the high resistance of the...
What are Carbohydrates?
Carbohydrate Digestion
Chemistry of Carbohydrates
Fats as Energy Storage Molecules

