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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
Published on: August 28, 2014
Evaluation of the scars' vascularization using computer processing of the digital images
Valerii Teplyi1, Kateryna Grebchenko1
1Department of Surgery #2, O.O. Bogomolets National Medical University, Kyiv, Ukraine.
Summary
Evaluating pathologic scars requires objective vascularization assessment. ImageJ software with manual correction offers a precise, cost-effective method for analyzing scar neovascularization.
Area of Science:
- Dermatology
- Medical Imaging
- Image Analysis
Background:
- Objective evaluation of scar vascularization is crucial for assessing new treatment techniques.
- Pathologic scars present challenges in objective assessment due to their complex vascular networks.
Purpose of the Study:
- To evaluate the effectiveness of the ImageJ digital program for assessing neovascularization in pathologic scars.
- To compare different image processing methods within ImageJ for scar vascularization analysis.
Main Methods:
- A cross-sectional study involving 25 patients with pathologic scars.
- Two image processing methods were compared: thresholding with manual correction and the Vessel Analysis plugin.
- Image processing time and precision of vessel selection were evaluated by independent investigators.
Main Results:
- Image processing with manual correction was statistically slower but yielded higher precision in vessel selection (80.4% vs. 72.6%).
- The Vessel Analysis plugin in ImageJ led to an overestimation of vascular density.
- Skeletonization methods were proposed to improve the accuracy of Vascular Length Density calculations.
Conclusions:
- ImageJ software provides a cost-effective and user-friendly approach for objective scar vascularization assessment.
- Manual correction during vessel selection enhances the precision of neovascularization analysis in pathologic scars.
