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Updated: Feb 3, 2026
10:01
In vitro Methylation Assay to Study Protein Arginine Methylation
Published on: October 5, 2014
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Recent Advances in Methylation: A Guide for Selecting Methylation Reagents.
1Medicinal Chemistry, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Sweden.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|October 18, 2018
Summary
This review details recent methylation chemistry advances, categorizing reagents and discussing challenges in amine and peptide methylation. It aids chemists in selecting reagents for flexible synthetic route planning.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Synthetic Chemistry
Background:
- Methylation is a fundamental structural modification in organic and medicinal chemistry.
- Understanding methylation reagents and their applications is crucial for synthetic chemists.
- Recent advancements necessitate a comprehensive overview of available methylation strategies.
Purpose of the Study:
- To review and categorize recent advances in methylation chemistry.
- To discuss challenges associated with specific methylation reactions, such as mono N-methylation of aliphatic amines and N-methylation of peptides.
- To provide guidance for chemists in selecting appropriate methylation reagents and strategies.
Main Methods:
- Literature review of recent advancements in methylation chemistry.
- Categorization of various methylation reagents based on their properties and applications.
- Analysis of challenges and solutions in specific methylation reactions.
Main Results:
- A comprehensive categorization of diverse methylation reagents.
- Identification of key challenges in mono N-methylation of aliphatic amines and N-methylation of peptides.
- Discussion of strategies for effective utilization of methylation reagents.
Conclusions:
- The review offers a valuable resource for chemists seeking to choose optimal methylation reagents.
- Understanding reagent scope and synthetic challenges enhances flexibility in synthetic route planning.
- Advances in methylation chemistry provide new opportunities for molecular synthesis.
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