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Updated: Feb 3, 2026
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Published on: November 6, 2017
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Implementing the Proclamation of Stroke and Potentially Preventable Dementias
Vladimir Hachinski1, Detlev Ganten2, Daniel Lackland3
11 Department of Clinical Neurological Sciences, 339 Windermere Road, Western University, London, Canada.
Summary
Preventing stroke may reduce dementia risk. Joint prevention of stroke, dementia, and heart disease is possible by managing shared risk factors like hypertension.
Area of Science:
- Neurology
- Cardiology
- Public Health
Background:
- Brain health is crucial for overall wellbeing and chronic disease management.
- Stroke and dementia are primary threats to brain health.
- Emerging evidence links stroke prevention to dementia risk reduction.
Purpose of the Study:
- To explore the connection between stroke prevention and dementia risk.
- To highlight opportunities for joint prevention of cerebrovascular and cognitive diseases.
- To advocate for a unified approach to managing shared risk factors.
Main Methods:
- Analysis of population studies on stroke and dementia incidence.
- Review of treatment outcomes for atrial fibrillation regarding stroke and dementia.
- Examination of early-stage Alzheimer disease pathology and vascular function.
- Investigation of cognitive impairment in heart and kidney failure.
Main Results:
- A large population study indicated a 32% decrease in stroke incidence and a 7% reduction in dementia incidence.
- Atrial fibrillation treatment led to stroke reduction and a 48% decrease in dementia.
- Early Alzheimer disease shows signs of vascular dysregulation.
- Cognitive impairment is associated with heart and kidney failure and may be reversible.
Conclusions:
- Shared risk factors, particularly hypertension, facilitate joint prevention of stroke, dementia, and heart disease.
- A coordinated global effort is needed for the prevention of stroke and potentially preventable dementias.
- This approach offers a significant opportunity to improve brain health and reduce the burden of chronic diseases.
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