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Demographic and Clinical Features of Pediatric Uveitis in Israel

Zohar Habot-Wilner1, Liran Tiosano2, Juan M Sanchez2

  • 1Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Ocular Immunology and Inflammation
|October 18, 2018
PubMed

Insights

Pediatric uveitis in Israel, predominantly anterior and chronic, showed good visual outcomes in most cases. Juvenile idiopathic arthritis was the most common systemic association, with toxoplasmosis a frequent cause of infectious posterior uveitis.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Immunology

Background:

  • Pediatric uveitis is a significant cause of vision loss in children.
  • Understanding the epidemiology and characteristics of pediatric uveitis is crucial for effective management.
  • Data on pediatric uveitis in Israel is limited.

Purpose of the Study:

  • To describe the epidemiology, etiology, ocular features, treatment, and visual outcomes of pediatric uveitis in Israel.
  • To compare findings with international data on pediatric uveitis.

Main Methods:

  • Retrospective analysis of 107 pediatric patients (182 eyes) diagnosed with uveitis.
  • Data collected from two tertiary uveitis centers in Israel.
  • Review of patient demographics, uveitis characteristics, systemic associations, ocular complications, and visual acuity.

Main Results:

  • The majority of cases were anterior, idiopathic, bilateral, and chronic uveitis.
  • Systemic associations were present in 36%, with juvenile idiopathic arthritis being most common.
  • Infectious uveitis, primarily toxoplasmosis, accounted for 37% of posterior uveitis.
  • Anterior segment complications (41%) included posterior synechiae, cataract, and band keratopathy.
  • Posterior segment complications included papillitis, epiretinal membrane, and macular atrophy.
  • Ninety-three percent of eyes achieved visual acuity >20/40 at final follow-up.

Conclusions:

  • The epidemiological and clinical patterns of pediatric uveitis in Israel resemble those in Western countries.
  • Pediatric uveitis in Israel has a generally favorable visual prognosis.
  • Early diagnosis and comprehensive management are key to achieving good visual outcomes.

Keywords:
AdolescentsTNF-α inhibitorsanterior uveitischildrencorticosteroidsintermediate uveitispanuveitisposterior uveitisuveitisuveitis complications

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