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Published on: November 27, 2019
Human Fasciolosis in Iran: A Meta-analysis Study
Masoud Behzadifar1, Nicola Luigi Bragazzi2, Meysam Behzadifar3
1Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran.
Human fasciolosis, a liver fluke infection, has a 2% seroprevalence in Iran. This study highlights the need for public health interventions to control this significant disease burden.
Area of Science:
- Parasitology
- Public Health
- Epidemiology
Background:
- Fasciolosis is a significant public health concern caused by liver flukes of the genus Fasciola.
- Iran is recognized as an endemic region for human fasciolosis.
Purpose of the Study:
- To determine the seroprevalence of human fasciolosis in Iran.
- To provide data for public health policy and intervention planning.
Main Methods:
- A systematic literature search was performed across major scientific databases (Embase, PubMed/MEDLINE, Web of Science, Google Scholar) and Iranian databases (SID, Magiran, Irandoc) from January 2000 to June 2016.
- Meta-analysis using the DerSimonian-Laird random model was employed to calculate the overall prevalence.
- Heterogeneity was assessed using I2 and Q tests, with meta-regressions conducted to explore sources of variation.
Main Results:
- Eleven studies were included in the analysis, revealing an overall seroprevalence rate of 2% (95% CI 1-5) for human fasciolosis in Iran.
- No statistically significant association was found between gender and disease prevalence.
- A non-significant increased odds ratio (OR=1.67) for developing fasciolosis was observed in individuals consuming vegetables compared to those who did not.
Conclusions:
- The findings provide crucial epidemiological data on human fasciolosis in Iran.
- Results can inform healthcare workers and policymakers in developing targeted prevention and control strategies.
- Further research may be needed to clarify risk factors and optimize public health interventions.
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