Related Experiment Video
Updated: Feb 3, 2026

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA
Published on: October 5, 2012
A Platform for Comprehensive Genomic Profiling in Human Cancers and Pharmacogenomics Therapy Selection
Tadayuki Kou1, Masashi Kanai2, Mayumi Kamada3
1Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. tadayuki@kuhp.kyoto-u.ac.jp.
Abstract:
Recent innovations in next-generation sequencing (NGS) technologies have enabled comprehensive genomic profiling of human cancers in the clinical setting. The ability to profile has launched a worldwide trend known as precision medicine, and the fusion of genomic profiling and pharmacogenomics is paving the way for precision medicine for cancer. The profiling is coupled with information about chemical therapies available to patients with specific genotypes. As a result, the chemogenomic space in play is not only the standard chemical and genome space but also the mutational genome and chemical space. In this chapter, we introduce clinical genomic profiling using an NGS-based multiplex gene assay (OncoPrime™) at Kyoto University Hospital.
Related Concept Videos
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Genomics
Targeted Cancer Therapies
There are several types of targeted therapies against...
Gene Therapy
Genome Size and the Evolution of New Genes
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

