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Updated: Feb 3, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Metal-free photocatalytic thiol-ene/thiol-yne reactions
Sarbjeet Kaur1, Gaoyuan Zhao, Evan Busch
1Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave, Albany, New York 12222, USA. twang3@albany.edu.
Abstract:
The organic photocatalyst (9-mesityl-10-methylacridinum tetrafluoroborate) in the presence of visible light is used to initiate thiol-ene and thiol-yne reactions. Thiyl radicals are generated upon quenching the photoexcited catalyst with a range of thiols. The highlighted mild nature of the reaction conditions allows a broad substrate scope of the reactants. Relying on this efficient metal-free condition, both thiol-ene and thiol-yne reactions between carbohydrates and peptides could be realized in excellent yields.
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