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Related Experiment Video

Updated: Feb 3, 2026

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
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Trans-allelic mutational effects at the Peg3 imprinted locus.

Corey L Bretz1, Joomyeong Kim1

  • 1Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.

Plos One
|October 19, 2018
PubMed
Summary

This study reveals novel allele interactions at the Peg3 imprinted locus. Maternal deletion of the Peg3-DMR up-regulates paternally expressed genes, showing unidirectional regulation.

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • Allelic interactions are crucial for gene function but not fully understood.
  • The Peg3 imprinted locus is a key area for studying gene regulation.

Purpose of the Study:

  • To investigate trans-allelic interactions at the Peg3 imprinted locus.
  • To determine the role of the Peg3 Imprinting Control Region (Peg3-DMR) in gene regulation.

Main Methods:

  • Utilized mutant alleles targeting the Peg3-DMR.
  • Analyzed gene expression of paternally expressed genes (Peg3, Usp29) in various tissues and developmental stages.

Main Results:

  • Maternal deletion of Peg3-DMR caused a 2-fold upregulation of Peg3 and Usp29.

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  • These effects were consistent across tissues and developmental stages.
  • The observed trans-allelic effects were unidirectional, with maternal influence on the paternal allele.

    • Conclusions:

    • Identified previously unrecognized trans-allelic regulation associated with the Peg3-DMR.
    • Demonstrated that Peg3-DMR genetic manipulation, not other locus changes, drives these effects.
    • Highlighted the unidirectional nature of this regulatory mechanism.