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Trans-allelic mutational effects at the Peg3 imprinted locus.
Corey L Bretz1, Joomyeong Kim1
1Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, United States of America.
Plos One
|October 19, 2018
Summary
This study reveals novel allele interactions at the Peg3 imprinted locus. Maternal deletion of the Peg3-DMR up-regulates paternally expressed genes, showing unidirectional regulation.
Area of Science:
- Genetics
- Molecular Biology
- Developmental Biology
Background:
- Allelic interactions are crucial for gene function but not fully understood.
- The Peg3 imprinted locus is a key area for studying gene regulation.
Purpose of the Study:
- To investigate trans-allelic interactions at the Peg3 imprinted locus.
- To determine the role of the Peg3 Imprinting Control Region (Peg3-DMR) in gene regulation.
Main Methods:
- Utilized mutant alleles targeting the Peg3-DMR.
- Analyzed gene expression of paternally expressed genes (Peg3, Usp29) in various tissues and developmental stages.
Main Results:
- Maternal deletion of Peg3-DMR caused a 2-fold upregulation of Peg3 and Usp29.
- These effects were consistent across tissues and developmental stages.
- The observed trans-allelic effects were unidirectional, with maternal influence on the paternal allele.
Conclusions:
- Identified previously unrecognized trans-allelic regulation associated with the Peg3-DMR.
- Demonstrated that Peg3-DMR genetic manipulation, not other locus changes, drives these effects.
- Highlighted the unidirectional nature of this regulatory mechanism.
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