Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crossover Experiments01:16

Crossover Experiments

4.6K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.6K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.2K
Overview
80.2K
Ionic Crystal Structures02:42

Ionic Crystal Structures

17.0K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
17.0K
Contact Angle01:13

Contact Angle

19.7K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
19.7K
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.0K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.0K
Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

30.8K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
30.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A ROS-Responsive DNA Nanodevice for Targeted Cytosolic siRNA Delivery in Metabolic Dysfunction-Associated Steatohepatitis.

Journal of the American Chemical Society·2026
Same author

A synthetic cell microreactor with two types of interacting dynamic DNA-based pores.

Nature chemistry·2026
Same author

Electromagnetic vs Chemical Interfacial Interactions at the Single-Molecule-Confined Sub-nanometer Molecule-Metal Gap: A Solution-Phase Chiroptical Study.

Nano letters·2026
Same author

Scaling Up Sequential Stepwise DNA Displacement-Based Signal Exchange for Rapid Ultraplex Fluorescent Imaging in Cells and Tissues.

Journal of the American Chemical Society·2026
Same author

Designer RNA nanostructures co-transcribed and self-assembled inside human cell nuclei.

Nature communications·2025
Same author

High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography.

Nature communications·2025

Related Experiment Video

Updated: Feb 3, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.2K

Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering.

Fan Hong1, Shuoxing Jiang1, Xiang Lan1

  • 1Center for Molecular Design and Biomimetics at the Biodesign Institute and School of Molecular Sciences , Arizona State University , Tempe , Arizona 85287 , United States.

Journal of the American Chemical Society
|October 19, 2018
PubMed
Summary

Researchers developed new DNA tiles for bottom-up construction of 2D and 3D materials. These layered-crossover tiles enable precise control over lattice angles, expanding DNA nanotechnology capabilities.

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.1K
2D and 3D Echocardiography in the Axolotl Ambystoma Mexicanum
09:53

2D and 3D Echocardiography in the Axolotl Ambystoma Mexicanum

Published on: November 29, 2018

15.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.2K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.1K
2D and 3D Echocardiography in the Axolotl Ambystoma Mexicanum
09:53

2D and 3D Echocardiography in the Axolotl Ambystoma Mexicanum

Published on: November 29, 2018

15.6K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biotechnology

Background:

  • DNA tile-based assembly is a key bottom-up strategy for creating designer nanoscale structures.
  • Existing methods have limitations in controlling the precise orientation and angles of assembled lattices.
  • The development of novel DNA tile designs is crucial for advancing complex material fabrication.

Purpose of the Study:

  • To introduce a novel class of DNA tiles, termed layered-crossover tiles.
  • To demonstrate the capability of these tiles in assembling 2D and 3D crystalline structures with controlled angles.
  • To expand the toolkit for DNA nanotechnology in bottom-up material construction.

Main Methods:

  • Design of layered-crossover DNA tiles, each incorporating two or four pairs of layered crossovers.
  • Utilizing specific sticky-end matching rules to direct tile self-assembly.
  • Characterization of assembled 2D periodic lattices and 3D lattices with tunable angles.

Main Results:

  • Layered-crossover tiles successfully assembled into 2D periodic lattices with precisely controlled angles (20°–80°).
  • Modified tiles were used to construct 3D lattices with dimensions of several hundred micrometers and tunable angles.
  • The new tiles offer enhanced control over the relative orientation of DNA helices in adjacent layers.

Conclusions:

  • Layered-crossover tiles represent a significant advancement in DNA tile design.
  • This innovation enables the precise construction of complex 2D and 3D DNA-based materials.
  • The findings broaden the scope of DNA nanotechnology for creating functional materials.