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Related Experiment Video

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Linking Predation Risk, Herbivore Physiological Stress and Microbial Decomposition of Plant Litter

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Published on: March 12, 2013

Predator odor stress blunts alcohol conditioned aversion.

Allyson L Schreiber¹, M Adrienne McGinn¹, Scott Edwards²

¹Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, United States.

Neuropharmacology

|October 19, 2018

Summary

This summary is machine-generated.

Traumatic stress history blunts the aversive effects of moderate alcohol doses in rats. This stress-induced change in alcohol aversion is linked to molecular alterations in the extended amygdala, impacting reward pathways.

Keywords:

Alcohol reward Place conditioning Post-traumatic stress disorder (PTSD)

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Area of Science:

Neuroscience
Behavioral Pharmacology
Addiction Research

Background:

Alcohol use disorder frequently co-occurs with traumatic stress disorders.
Individuals with dual diagnoses often report drinking alcohol to cope with negative affective symptoms.
Traumatic stress may alter the rewarding and aversive properties of alcohol.

Purpose of the Study:

To investigate how traumatic stress history affects the rewarding and aversive properties of alcohol.
To examine the neurobiological underpinnings of stress-induced changes in alcohol's effects.
To explore the role of the extended amygdala in mediating these interactions.

Main Methods:

Utilized a place conditioning procedure in adult male Wistar rats to assess alcohol's rewarding/aversive properties.
Manipulated traumatic stress history (predator odor exposure) and alcohol drinking history.
Measured CREB phosphorylation (pCREB) and striatal-enriched protein tyrosine phosphatase (STEP) expression in the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST).

Main Results:

A moderate alcohol dose (1.0 g/kg) induced conditioned place aversion (CPA), which was blunted by stress history.
Stress history reduced pCREB expression in the BNST, irrespective of alcohol drinking history.
Acute alcohol's effects on pCREB and STEP in the CeA correlated with alcohol preference.

Conclusions:

Traumatic stress history reduces the aversive properties of moderate alcohol doses.
Alcohol aversion is associated with acute alcohol-induced changes in pCREB and STEP expression within the extended amygdala.
These findings highlight a potential neurobiological mechanism linking stress and alcohol use disorder.