Biomimetic cofactors and methods for their recycling
Ioannis Zachos1, Claudia Nowak2, Volker Sieber3
1Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany.
Current Opinion in Chemical Biology
|October 19, 2018
Summary
Nicotinamide cofactor biomimetics (NCBs) mimic natural cofactors for biochemical studies and biocatalysis. Recent advancements have led to new NCBs for efficient enzymatic reactions.
Area of Science:
- Biochemistry
- Organic Chemistry
Background:
- Nicotinamide cofactor biomimetics (NCBs) are compounds designed to replicate the function of natural nicotinamide cofactors like NAD+ and NADP+.
- First discovered in the 1930s, NCBs were initially employed to investigate cofactor chemical properties and enzyme binding mechanisms.
Purpose of the Study:
- To provide an overview of the historical development and modern applications of nicotinamide cofactor biomimetics.
- To highlight the evolution of NCBs, associated enzymes, and recycling systems in biocatalysis.
Main Methods:
- Literature review of NCB development and applications.
- Analysis of historical and recent research in cofactor biomimetics and biocatalysis.
Main Results:
- NCBs have evolved significantly since their initial discovery.
- Newer NCBs are being developed and utilized for advanced biocatalytic processes.
Conclusions:
- Nicotinamide cofactor biomimetics are versatile tools in biochemistry and biocatalysis.
- Ongoing research continues to expand the utility and efficiency of NCBs in chemical synthesis and enzymatic reactions.
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