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Updated: Feb 3, 2026

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
[Biomarkers predictive of PD1/PD-L1 immunotherapy in non-small cell lung cancer]
A Lupo1, M Alifano2, M Wislez3
1UMRS 1138, Institut national de la santé et de la recherche médicale (Inserm), centre de recherche des cordeliers équipe « Cancer, Immune Control and Escape », Paris, France; Université Paris Descartes, 75006 Paris, France; Université Pierre et Marie-Curie Paris, 75005 Paris, France; Service de pathologie, hôpital Cochin, Assistance publique des hôpitaux de Paris (AP-HP), 75014 Paris, France.
Abstract:
Immune checkpoint inhibitors (ICI), targeting the PD1/PD-L1 axis has shown their efficacy in lung cancer but only in a restricted population of patients, thus it is mandatory to identify biomarkers predicting the clinical benefit. In this article we will describe and analyzed biomarkers already published, from protein, to RNA and at last DNA markers, discussing each markers feasibility and interest. In the future, combined analysis of several markers will probably be proposed, particularly with the increasing complexity of therapy schema with molecules association.
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