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P-N junction

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A p-n junction is formed when p-type and n-type semiconductor materials are joined together. At the interface of the p-n junction, holes from the p-side and electrons from the n-side begin to diffuse into the opposite sides due to the concentration gradient. This diffusion of carriers leads to a region around the junction where there are no free charge carriers, known as the depletion region. The charge density within the depletion region for the n-side and p-side can be described by the...
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The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Adherens Junctions01:24

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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Gap Junctions01:27

Gap Junctions

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The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
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Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
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Updated: Feb 3, 2026

Photodiode-Based Optical Imaging for Recording Network Dynamics with Single-Neuron Resolution in Non-Transgenic Invertebrates
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Filterless optical oxygen sensor based on a CMOS buried double junction photodiode.

Zhiyong Zhan1, Bin Zhou1, Zhenhong Fu2

  • 1Department of Electrical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

Sensors and Actuators. B, Chemical
|October 20, 2018
PubMed
Summary
This summary is machine-generated.

We developed a custom integrated circuit with a buried double junction photodiode for optical signal detection. This chip integrates signal processing to reduce noise and offers low-cost, low-power performance without external filters.

Keywords:
CMOS photodetectorsDNA–CTMA sensorFilterless color detectionOxygen sensor

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Area of Science:

  • Integrated circuit design
  • Optoelectronics
  • Semiconductor device physics

Background:

  • Optical signal detection often requires bulky and expensive off-chip filters.
  • Extracting desired signals from optical noise is a significant challenge in many applications.
  • Existing solutions can be power-hungry and costly to manufacture.

Purpose of the Study:

  • To present a novel custom CMOS integrated circuit (IC) for optical signal detection and processing.
  • To eliminate the need for external optical filters through on-chip integration.
  • To achieve low-cost fabrication and low power consumption.

Main Methods:

  • Design and fabrication of a custom CMOS IC incorporating a buried double junction (BDJ) photodiode.
  • Integration of on-chip signal processing circuitry for enhanced signal extraction.
  • Utilizing standard commercial fabrication processes without post-processing.

Main Results:

  • Successful integration of a BDJ photodiode and signal processing on a single CMOS IC.
  • Demonstrated elimination of the requirement for off-chip optical filters.
  • Achieved improved signal extraction from optical background noise.
  • Verified low-cost fabrication potential due to standard CMOS processes.
  • Confirmed low operating and standby power consumption.

Conclusions:

  • The custom CMOS IC with BDJ photodiode offers a compact, efficient, and cost-effective solution for optical signal detection.
  • On-chip signal processing significantly enhances signal quality by mitigating background noise.
  • The integration enables reduced system complexity, power consumption, and manufacturing costs.