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Updated: Feb 3, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Takayasu Arteritis.

Ricardo A G Russo¹, María M Katsicas¹

¹Service of Immunology & Rheumatology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Frontiers in Pediatrics

|October 20, 2018

Summary

This summary is machine-generated.

Takayasu arteritis, a vasculitis affecting the aorta, causes vessel damage and diverse symptoms. Early diagnosis and treatment are crucial for managing this severe condition in children and adults.

Keywords:

Takayasu aorta arteritis children large vessel vasculitis

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Last Updated: Feb 3, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch

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Published on: May 11, 2011

Area of Science:

Vascular Medicine
Pediatric Rheumatology
Immunology

Background:

Takayasu arteritis is an idiopathic granulomatous vasculitis affecting the aorta and its major branches.
It is a common vasculitis in pediatric populations, causing inflammation, stenosis, aneurysms, and thrombosis.
Clinical features include carotid artery tenderness, claudication, ocular disturbances, CNS abnormalities, and diminished pulses.

Purpose of the Study:

To review current knowledge on Takayasu arteritis pathogenesis, diagnosis, classification, and management.
To highlight the importance of timely diagnosis and effective therapeutic interventions.
To emphasize the need for close patient monitoring in Takayasu arteritis.

Main Methods:

Review of existing literature on Takayasu arteritis.
Analysis of diagnostic criteria, including imaging modalities like angiography, MRA, and CTA.
Synthesis of information on pathogenesis, clinical presentation, and management strategies.

Main Results:

Inflammation and intimal proliferation lead to aortic wall thickening, stenosis, occlusion, and thrombosis.
Destruction of aortic wall layers results in aneurysms and dissection.
Diagnostic confirmation relies on identifying large vessel abnormalities via imaging.

Conclusions:

Takayasu arteritis requires timely diagnosis, effective treatment, and vigilant monitoring.
Understanding pathogenesis and diagnostic findings is key to managing this severe condition.
This review synthesizes current knowledge to guide clinical practice and research.