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Increased 30-Day Mortality Associated With Carbapenem-Resistant Enterobacteriaceae in Children
Kathleen Chiotos1,2,3, Pranita D Tamma4, Kelly B Flett5
1Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Open Forum Infectious Diseases
|October 20, 2018
Insights
Hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) face higher mortality risks. Antibiotic treatment for pediatric CRE infections shows significant variation, with combination therapy infrequently used.
Area of Science:
- Infectious Diseases
- Pediatric Medicine
- Antimicrobial Resistance
Background:
- Carbapenem-resistant Enterobacteriaceae (CRE) pose a significant threat in healthcare settings.
- Pediatric populations may experience unique challenges with CRE infections.
- Understanding mortality risks and treatment patterns in children is crucial.
Purpose of the Study:
- To determine the 30-day mortality risk associated with CRE infections in hospitalized children.
- To analyze the patterns of antibiotic treatment for pediatric CRE infections.
- To identify variations in the use of combination antibiotic therapy.
Main Methods:
- Multicenter study design.
- Analysis of clinical cultures from hospitalized children.
- Comparison of outcomes between carbapenem-resistant and carbapenem-susceptible Enterobacteriaceae isolates.
Main Results:
- An increased risk of 30-day mortality was identified in children with CRE compared to susceptible strains.
- Significant variation in prescribed antibiotic treatments for pediatric CRE infections was observed.
- Combination antibiotic therapy was infrequently utilized in the treatment of these children.
Conclusions:
- CRE infections in hospitalized children are associated with a higher risk of mortality.
- Current antibiotic treatment strategies for pediatric CRE infections are highly variable.
- Further research into optimal combination therapy for pediatric CRE is warranted.
Abstract:
In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.
Keywords:
Gram-negative resistanceKlebsiella pneumoniae carbapenemasemultidrug-resistant organismpediatricsMore Related Videos
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