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Cu(i)/{Nb6O19} catalyzed N-acylation of arylacetic acids with amines under aerobic conditions
Pei-He Li1, Zheng Wang2, Hui Fu2
1Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China. daiqipu@bit.edu.cn cwhu@bit.edu.cn and Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), College of Chemistry and Chemical Engineering, Inner Mongolia University for Nationalities, Tongliao 028000, China.
Abstract:
The method described herein is a general, efficient and green approach to synthesize α-ketoamides from arylacetic acids and amines. Employing a simple copper(i)/{Nb6O19} catalyst system, the reaction offers a facile process to give functionalized α-ketoamides from readily available arylacetic acids under aerobic conditions. The merit of this new strategy is that it expands the syntheses of α-ketoamides from stable, inexpensive and widely available acylation reagents such as arylacetic acids in one step.
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