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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
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Human polyomavirus KI, WU, BK, and JC in healthy volunteers

Giselle P A Pena1, Gabriella S Mendes1, Helver G Dias1

  • 1Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|October 20, 2018
PubMed

Insights

Human polyomaviruses (HPyVs) are common in healthy Brazilians, with varied excretion patterns across regions. This study analyzed HPyV1-4 in saliva, revealing significant geographic differences in viral distribution.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human polyomaviruses (HPyVs) are increasingly recognized pathogens, yet their epidemiology and transmission remain poorly understood.
  • Limited data exists on the prevalence and distribution of HPyVs in asymptomatic populations, particularly in diverse geographic settings like Brazil.

Purpose of the Study:

  • To investigate the excretion and geographic distribution of four common HPyVs (HPyV1-4) in asymptomatic individuals across Brazil.
  • To identify potential distinct epidemiologic patterns of HPyV infection within the Brazilian population.

Main Methods:

  • Real-time polymerase chain reaction (PCR) was used to detect HPyV1-4 in saliva samples.
  • 889 healthy volunteers from nine different geographic locations in Brazil participated in the study.

Main Results:

  • 39% of participants (346/889) showed evidence of infection with at least one HPyV species.
  • HPyV1 was the most prevalent (14.3%), followed by HPyV3 (7.9%), HPyV4 (6.7%), and HPyV2 (2.8%).
  • Coinfections with multiple HPyVs were detected in 7.3% of participants, with significant variations in HPyV species frequency and distribution across geographic regions.

Conclusions:

  • The four studied HPyV species are actively circulating in Brazil, with common salivary excretion observed in healthy individuals.
  • Significant regional variations in the prevalence and distribution of HPyV species highlight the need for geographically specific epidemiological surveillance.
  • These findings contribute to a better understanding of HPyV epidemiology in Brazil and underscore the importance of considering regional differences.
Keywords:
BKPyVJCPyVKIPyVPolyomavirusesSalivaWUPyV

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