Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

50.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.3K
Nucleic acids02:43

Nucleic acids

189.7K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
189.7K
Nucleic Acids02:43

Nucleic Acids

9.0K
9.0K
Nucleic Acid Structure01:25

Nucleic Acid Structure

8.9K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
8.9K
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

14.6K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
14.6K
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

1.1K
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intractable Ocular Diseases and Treatment Progress.

AAPS PharmSciTech·2020
Same author

Progress on ocular siRNA gene-silencing therapy and drug delivery systems.

Fundamental & clinical pharmacology·2020
Same author

Synthesis and Characterization of Quaternized Poly(β-amino ester) for Highly Efficient Delivery of Small Interfering RNA.

Molecular pharmaceutics·2018
Same author

Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites.

BMB reports·2008
Same author

The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis.

The Journal of biological chemistry·2008
Same author

Monitoring prostate thermal therapy with diffusion-weighted MRI.

Magnetic resonance in medicine·2008

Related Experiment Video

Updated: Feb 3, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

8.7K

Nucleic Acid-Based Therapeutics for Pulmonary Diseases.

Jing Chen1, Yue Tang2, Yun Liu1

  • 1Department of Pharmacy, China Pharmaceutical University, No.639, Longmian Avenue, Nanjing, 211198, People's Republic of China.

AAPS Pharmscitech
|October 20, 2018
PubMed
Summary

Nucleic acid therapies show promise for lung diseases like cancer and asthma. Effective delivery and safety are key challenges for clinical use of these pulmonary drug treatments.

Keywords:
antisense oligonucleotide (ASO)microRNA (miRNA)nucleic acidpulmonary diseasesshort interfering RNA (siRNA)

More Related Videos

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

8.4K
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

8.7K
A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

8.4K
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.6K

Area of Science:

  • Biomedical Engineering
  • Pulmonary Medicine
  • Pharmacology

Background:

  • Nucleic acid-based therapeutics offer significant potential for treating prevalent and fatal pulmonary diseases, including lung cancer, asthma, and chronic obstructive pulmonary disease.
  • Effective pulmonary delivery of nucleic acid drugs is hindered by nucleic acid degradation and the complex lung structure.
  • Current limitations such as off-target effects and immune stimulation impede the clinical translation of these advanced therapies.

Purpose of the Study:

  • To provide a comprehensive review of nucleic acid applications in treating pulmonary diseases.
  • To explore novel delivery systems and formulations for pulmonary administration of nucleic acid drugs.
  • To detail the latest clinical advances in nucleic acid-based treatments for lung disorders.

Main Methods:

  • Review of existing literature on nucleic acid therapeutics for pulmonary diseases.
  • Analysis of various delivery strategies including chemical synthesis, vector encapsulation, formulation, and administration routes.
  • Examination of clinical trial data for nucleic acid drugs targeting lung conditions.

Main Results:

  • Various strategies like chemical synthesis, vector encapsulation, and optimized formulations enhance pulmonary delivery of nucleic acids.
  • Understanding the action mechanisms and addressing off-target effects and immune responses are crucial for clinical success.
  • Several nucleic acid drugs are currently under clinical evaluation for pulmonary disorders, indicating progress in the field.

Conclusions:

  • Well-developed carriers and administration methods are essential to ensure the safety and efficacy of nucleic acid drugs for pulmonary diseases.
  • Continued research into novel delivery systems and formulations is vital for overcoming current limitations.
  • The clinical application of nucleic acid therapeutics for lung conditions is advancing, with ongoing trials showing promising results.